Systems and Production


Preservative-free nasal spray – made possible by a state-of-the-art application system

Nasal sprays quickly decongest the nose, which is why they are very popular and frequently used in rhinitis. However, many products contain preservatives such as benzalkonium chloride, which have been the focus of criticism for some time. These antiseptic agents are supposed to kill microorganisms in preparations and hence ensure their stability in multi-dose containers after opening. Preservatives such as benzalkonium chloride can, however, cause allergic reactions such as swelling, redness or itching. Therefore, consumers should preferably use nasal sprays without preservatives.

The 3K® system does away with preservatives

The 3K® system is a state-of-the-art application system for dispensing liquid pharmaceutical preparations that keeps contents sterile during storage and use. Therefore, no preservatives such as benzalkonium chloride are necessary. The core of the 3K® system is the so-called NON-AIRLESS pump, which reliably prevents contamination of the container’s contents with microorganisms.

How does the 3K® system work?

The 3K® system has been tried and tested in the past, in particular for solutions for nasal application (nasal sprays). It works as follows: A built-in valve releases the nasal spray when the pump is depressed without allowing air to flow back into the bottle. The air passes a special filter matrix that consists of an efficient material combination of filter, adsorption materials and silver.
Consumers who need a rhinitis spray or a lubricating nasal spray without preservatives can choose from the entire hysan® product range: hysan® rhinitis-spray, hysan® care spray, hysan® hyaluronic acid spray and hysan® saline spray. Thanks to the state-of-the-art 3K® system, all of them are completely free of preservatives.

Advantages at a glance

URSAPHARM products without preservatives that come in the proven 3K® system offer the following advantages:

  • Sterility without preservatives
  • Shelf life of 6 months after opening
  • High dosing accuracy
  • Excellent tolerability

The system of the future in Europe and throughout the world

Consumers are increasingly aware of the contents of medicinal products and medical devices and are making more of a conscious decision when choosing products in order to prevent possible intolerances. This gives nasal sprays without preservatives a decisive competitive advantage. The 3K® system significantly contributes to the safety and tolerability of nasal sprays. Therefore, this innovation will play a key role in the future of nasal sprays in Europe and worldwide.


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